Genovese Crime Family is an criminal organization led by John Genovese, and later by John's brother Ralph. Chris Genovese tries to take over. However, both John and Ralph were killed, leaving the organization to their third brother, Don Genovese. Chris is in the hospital after his fight with Kick-Ass. The entire family is killed by Hit-Girl during the ending of Kick-Ass 3.

They are the main antagonists of the Kick-Ass and Hit-Girl comic series.